Bak1^tm1.1Zdong
Targeted Allele Detail

Summary

• Symbol: Bak1^tm1.1Zdong
• Name: BCL2-antagonist/killer 1; targeted mutation 1.1, Zheng Dong
• MGI ID: MGI:6392849
• Synonyms: Bak(flox)
• Gene: Bak1 Location: Chr17:27238786-27247601 bp, - strand Genetic Position: Chr17, 13.65 cM, cytoband B
• Alliance: Bak1^tm1.1Zdong page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:274601
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting vector containing a FRT site flanked Neo selection cassette and a loxP site was inserted upstream of exon 3 of the targeted gene, and another loxP site was inserted upstream of exon 4. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:274601)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bak1 Mutation: 26 strains or lines available

References

• Original: J:274601 Mei S, et al., Double knockout of Bax and Bak from kidney proximal tubules reduces unilateral urethral obstruction associated apoptosis and renal interstitial fibrosis. Sci Rep. 2017 Mar 20;7:44892
• All: 1 reference(s)