Bdnf^tm1.1Xen
Targeted Allele Detail

Summary

• Symbol: Bdnf^tm1.1Xen
• Name: brain derived neurotrophic factor; targeted mutation 1.1, Taconic Biosciences
• MGI ID: MGI:6392346
• Synonyms: BDNF^met, Met68BDNF KI
• Gene: Bdnf Location: Chr2:109505045-109557352 bp, + strand Genetic Position: Chr2, 56.63 cM
• Alliance: Bdnf^tm1.1Xen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:284662
• Parent Cell Line: B6-3i/HK3i (ES Cell)
• Strain of Origin: C57BL/6NJcl

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 9 was replaced with a floxed neomycin resistance cassette and a modified exon 9 with the nucleotide substitution of GCT to ATG that results in the amino acid substitution of methionine for valine at position 68. This mutation mimics a human polymorphism associated with psychiatric disorders. Cre-mediated recombination removed the selection cassette. (J:284662)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bdnf Mutation: 42 strains or lines available

References

• Original: J:284662 Warnault V, et al., The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation. Biol Psychiatry. 2016 Mar 15;79(6):463-73
• All: 3 reference(s)