Mirc29^tm1.1Bdes
Targeted Allele Detail

Summary

• Symbol: Mirc29^tm1.1Bdes
• Name: microRNA cluster 29, including Mir29b-2 through Mir29c; targeted mutation 1.1, Bart de Stropper
• MGI ID: MGI:6392145
• Synonyms: mir-29c^-
• Gene: Mirc29 Location: Chr1:194719348-194719942 bp Genetic Position: Chr1, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:246547
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and hygromycin resistance cassette were inserted upstream of Mir29b-2. An additional loxP site was inserted downstream of Mir29c. Cre-mediated recombination removed the selection cassette along with both microRNA regions. (J:246547)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mirc29 Mutation: 1 strain or line available

References

• Original: J:246547 Dooley J, et al., The microRNA-29 Family Dictates the Balance Between Homeostatic and Pathological Glucose Handling in Diabetes and Obesity. Diabetes. 2016 Jan;65(1):53-61
• All: 2 reference(s)