Fancd2^em1Tzh
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fancd2^em1Tzh
• Name: Fanconi anemia, complementation group D2; endonuclease-mediated mutation 1, Tingting Zhang
• MGI ID: MGI:6392092
• Gene: Fancd2 Location: Chr6:113508643-113573978 bp, + strand Genetic Position: Chr6, 52.78 cM, cytoband E3
• Alliance: Fancd2^em1Tzh page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 technology generated a 7 bp deletion (ACACTGA) in exon 5. (J:284566)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fancd2 Mutation: 81 strains or lines available

References

• Original: J:284566 Yang Q, et al., Severe Fanconi Anemia phenotypes in Fancd2 depletion mice. Biochem Biophys Res Commun. 2019 Jun 30;514(3):713-719
• All: 1 reference(s)