Champ1^em2Lutzy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Champ1^em2Lutzy
• Name: chromosome alignment maintaining phosphoprotein 1; endonuclease-mediated mutation 2, Cathy Lutz
• MGI ID: MGI:6392016
• Synonyms: Champ1 Ala129fs43Ter
• Gene: Champ1 Location: Chr8:13919699-13931637 bp, + strand Genetic Position: Chr8, 6.4 cM
• Alliance: Champ1^em2Lutzy page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing is used to introduce a null frameshift mutation. Specifically, a 3 bp deletion followed by a 1 bp insertion and a 9 bp deletion in exon 2 that is predicted to result in an alanine 129 frameshift that adds 43 new amino acids and results in premature termination. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Champ1 Mutation: 28 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 1 reference(s)