Kif21b^tm1.1Noh
Targeted Allele Detail

Summary

• Symbol: Kif21b^tm1.1Noh
• Name: kinesin family member 21B; targeted mutation 1.1, Nobutaka Hirokawa
• MGI ID: MGI:6391366
• Synonyms: Kif21b^2lox
• Gene: Kif21b Location: Chr1:136059127-136105736 bp, + strand Genetic Position: Chr1, 59.61 cM
• Alliance: Kif21b^tm1.1Noh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270808
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A KOMP project targeting vector was used to generate mutant mice. A loxP and frt-flanked lacZ gene and neomycin selection cassette was inserted upstream of exon 1 and a single loxP site was inserted downstream of exon 3. FLP-mediated recombination removed the lacZ gene and neomycin selection cassette, leaving lozP sites flanking exons 1-3. (J:270808)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kif21b Mutation: 89 strains or lines available

References

• Original: J:270808 Morikawa M, et al., The Molecular Motor KIF21B Mediates Synaptic Plasticity and Fear Extinction by Terminating Rac1 Activation. Cell Rep. 2018 Jun 26;23(13):3864-3877
• All: 1 reference(s)