Tg(TcraY4,TrcbY4)F2025Tdsc
Transgene Detail

Summary

• Symbol: Tg(TcraY4,TrcbY4)F2025Tdsc
• Name: transgene insertion F2025, Todd Schell
• MGI ID: MGI:6391061
• Synonyms: TCR-IV
• Transgene: Tg(TcraY4,TrcbY4)F2025Tdsc Location: unknown
• Alliance: Tg(TcraY4,TrcbY4)F2025Tdsc page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcraY4,TrcbY4)F2025Tdsc expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)	expresses Valpha15-Jalpha12
  mouse	Tcrb (MGI:98578)	expresses Vbeta9-Jbeta2.5

• Mutation details: The transgenic construct contains sequences from the alpha and beta-chains of the T cell receptor (TCR) from the SV40 large tumor antigen epitope IV-specific cytotoxic T lymphocyte clone Y-4. The TCR subunits express Vbeta9-Jbeta2.5 and Valpha15-Jalpha12. (J:142961)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:142961 Tatum AM, et al., CD8+ T cells targeting a single immunodominant epitope are sufficient for elimination of established SV40 T antigen-induced brain tumors. J Immunol. 2008 Sep 15;181(6):4406-17
• All: 1 reference(s)