Atxn2^tm3.1Aub
Targeted Allele Detail

Summary

• Symbol: Atxn2^tm3.1Aub
• Name: ataxin 2; targeted mutation 3.1, Georg Auburger
• MGI ID: MGI:6389582
• Synonyms: Atxn2-CAG100, Atxn2^tm3.1Geno
• Gene: Atxn2 Location: Chr5:121849794-121954372 bp, + strand Genetic Position: Chr5, 61.93 cM, cytoband F
• Alliance: Atxn2^tm3.1Aub page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:283871
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Single point mutation
• Mutation details: Exon 1 was modified with the insertion of a CAG100 repeat at position Q156 and a G to A nucleotide restriction site 422 bp upstream the CAG repeat. Flp-mediated recombination removed the FRT-flanked neomycin resistance cassette inserted downstream of the modified exon 1. (J:283871)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atxn2 Mutation: 90 strains or lines available

References

• Original: J:283871 Sen NE, et al., Generation of an Atxn2-CAG100 knock-in mouse reveals N-acetylaspartate production deficit due to early Nat8l dysregulation. Neurobiol Dis. 2019;132:104559
• All: 6 reference(s)