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Oprm1IAP
Spontaneous Allele Detail
Nomenclature
Symbol: Oprm1IAP
Name: opioid receptor, mu 1; intracisternal-A particle insertion
MGI ID: MGI:6388520
Synonyms: Oprm1CXBK
Gene: Oprm1  Location: Chr10:6708593-6988209 bp, + strand  Genetic Position: Chr10, 1.85 cM, cytoband A2
Mutation
origin
Strain of Origin:  CXB7/ByJ
Mutation
description
Allele Type:    Spontaneous (Hypomorph)
Mutation:    Insertion
 
Mutation detailsSequencing of the gene revealed a 5293 nucleotide insertion in the 3' noncoding region. The inserted sequence is a variant of the intracisternal A-particle elements. Mice carrying this allele express a reduced amount of the major gene transcript. The encoded mRNA contains a normal coding region and an abnormally long untranslated region. (J:283376)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Oprm1 Mutation:  42 strains or lines available
References
Original:  J:283376 Han W, et al., Intracisternal A-particle element in the 3' noncoding region of the mu-opioid receptor gene in CXBK mice: a new genetic mechanism underlying differences in opioid sensitivity. Pharmacogenet Genomics. 2006 Jun;16(6):451-60
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory