Oprm1^IAP
Spontaneous Allele Detail

Summary

• Symbol: Oprm1^IAP
• Name: opioid receptor, mu 1; intracisternal-A particle insertion
• MGI ID: MGI:6388520
• Synonyms: Oprm1^CXBK
• Gene: Oprm1 Location: Chr10:6708593-6988209 bp, + strand Genetic Position: Chr10, 1.85 cM, cytoband A2
• Alliance: Oprm1^IAP page

Mutation origin

• Strain of Origin: CXB7/ByJ

Mutation description

• Allele Type: Spontaneous (Hypomorph)
• Mutation: Insertion
• Mutation details: Sequencing of the gene revealed a 5293 nucleotide insertion in the 3' noncoding region. The inserted sequence is a variant of the intracisternal A-particle elements. Mice carrying this allele express a reduced amount of the major gene transcript. The encoded mRNA contains a normal coding region and an abnormally long untranslated region. (J:283376)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Oprm1 Mutation: 53 strains or lines available

References

• Original: J:283376 Han W, et al., Intracisternal A-particle element in the 3' noncoding region of the mu-opioid receptor gene in CXBK mice: a new genetic mechanism underlying differences in opioid sensitivity. Pharmacogenet Genomics. 2006 Jun;16(6):451-60
• All: 2 reference(s)