Tg(Rho-Pdcl*)#Msok
Transgene Detail

Summary

• Symbol: Tg(Rho-Pdcl*)#Msok
• Name: transgene insertion, Maxim Sokolov
• MGI ID: MGI:6386387
• Synonyms: ^delta1-83PhLP
• Transgene: Tg(Rho-Pdcl*)#Msok Location: unknown
• Alliance: Tg(Rho-Pdcl*)#Msok page

Transgene origin

• Strain of Origin: 129

Transgene description

• Transgene Type: Transgenic (Dominant negative, Epitope tag, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Rho-Pdcl*)#Msok expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Pdcl (MGI:1914716)	N-terminally truncated which begins at the 84th codon

• Mutation details: The transgene consists of an N-terminally truncated mouse phosducin-like cDNA that begins with the 84th codon, which is an ATG, containing a C-terminal FLAG tag under the control of the mouse 4.4 kb rhodopsin promotor. This truncation produces a dominant-negative mutant that suppresses Tcp1 activity. The pound symbol (#) is used when line is not specified and/or lines are pooled. (J:283225)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:283225 Posokhova E, et al., Disruption of the chaperonin containing TCP-1 function affects protein networks essential for rod outer segment morphogenesis and survival. Mol Cell Proteomics. 2011 Jan;10(1):M110.000570
• All: 1 reference(s)