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Pxkem1(IMPC)Tcp
Endonuclease-mediated Allele Detail
Summary
Symbol: Pxkem1(IMPC)Tcp
Name: PX domain containing serine/threonine kinase; endonuclease-mediated mutation 1, The Centre for Phenogenomics
MGI ID: MGI:6385270
Gene: Pxk  Location: Chr14:14304656-14371562 bp, - strand  Genetic Position: Chr14, 4.7 cM
Alliance: Pxkem1(IMPC)Tcp page
IMPC: Pxk gene page
Mutation
origin
Strain of Origin:  C57BL/6NCrl
Project Collection: IMPC
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThis allele from project TCPR1481 was generated at The Centre for Phenogenomics by electroporating Cas9 ribonucleoprotein complexes with single guide RNAs having spacer sequences of GTTAACAGGTATCAGCGTCA targeting the 5' side and GACGTCCTTTACGCCAGTGT targeting the 3' side of a critical region. This resulted in a 1193-bp deletion Chr14: 8137054-8138246, p.(G156Afs*13) (GRCm38). (J:265051)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Pxk Mutation:  39 strains or lines available
References
Original:  J:265051 MGI and IMPC, MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC). Database Release. 2018-2023;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory