Gsdmd^tm1.1Cya
Targeted Allele Detail

Summary

• Symbol: Gsdmd^tm1.1Cya
• Name: gasdermin D; targeted mutation 1.1, Cyagen Biosciences
• MGI ID: MGI:6385110
• Synonyms: Gsdmd^flox, Gsdmd^tm1.1Cgen
• Gene: Gsdmd Location: Chr15:75734176-75739257 bp, + strand Genetic Position: Chr15, 35.0 cM, cytoband D3-E1
• Alliance: Gsdmd^tm1.1Cya page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:282786
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 3 was flanked by loxP sites and a neomycin cassette flanked by Rox sites was inserted after exon 3 but before the second loxP site. The neomycin selection cassette self-excised leaving exon 3 floxed. (J:282786)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gsdmd Mutation: 35 strains or lines available

References

• Original: J:282786 Li S, et al., Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis. J Exp Med. 2019 Nov 4;216(11):2562-2581
• All: 5 reference(s)