Tnni3k^em2Hsv
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tnni3k^em2Hsv
• Name: TNNI3 interacting kinase; endonuclease-mediated mutation 2, Henry M Sucov
• MGI ID: MGI:6384881
• Synonyms: Tnni3k delta4
• Gene: Tnni3k Location: Chr3:154491928-154761044 bp, - strand Genetic Position: Chr3, 79.32 cM
• Alliance: Tnni3k^em2Hsv page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing is used to introduce a 4 bp deletion (position 154939648-651 of NC_000069.6) in exon 16. The mutation results in a frameshift after Ser532 and in termination downstream after 29 ectopic domains. (J:280429)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnni3k Mutation: 47 strains or lines available

References

• Original: J:280429 Gan P, et al., Tnni3k alleles influence ventricular mononuclear diploid cardiomyocyte frequency. PLoS Genet. 2019 Oct;15(10):e1008354
• All: 1 reference(s)