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Targeted Allele Detail
Symbol: Btbd9tm1c(EUCOMM)Wtsi
Name: BTB (POZ) domain containing 9; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID: MGI:6384248
Synonyms: Btbd9 loxP
Gene: Btbd9  Location: Chr17:30434498-30795462 bp, - strand  Genetic Position: Chr17, 15.62 cM, cytoband B1
Mutant Cell Line:  EPD0631_3_A09
Germline Transmission:  Earliest citation of germline transmission: J:282582
Parent Cell Line:  JM8A3.N1 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Project Collection: EUCOMM
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion     Vector: L1L2_Bact_P
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 30525400 of Chromosome 17 upstream of the critical exon 4 (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 4 at position 30524425. The critical exon 4 is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon 4. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:282582)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Btbd9 Mutation:  40 strains or lines available
Original:  J:282582 Lyu S, et al., The role of BTBD9 in the cerebral cortex and the pathogenesis of restless legs syndrome. Exp Neurol. 2020 Jan;323:113111
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory