Fgf18tm2.1Dor
Targeted Allele Detail
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Symbol: |
Fgf18tm2.1Dor |
Name: |
fibroblast growth factor 18; targeted mutation 2.1, David M Ornitz |
MGI ID: |
MGI:6382297 |
Synonyms: |
Fgf18flox |
Gene: |
Fgf18 Location: Chr11:33067430-33097400 bp, - strand Genetic Position: Chr11, 19.21 cM
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Alliance: |
Fgf18tm2.1Dor page
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Germline Transmission: |
Earliest citation of germline transmission:
J:279323
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
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Mutation details: A multifunctional targeting vector inserted a splice acceptor (SA)-eGFP:CreERT2 fusion gene into the intron located between Fgf18 exons 1B and 1C along with a PGK-neo selection cassette. Additional Frt and LoxP recombination sites were placed in the targeted allele to allow the generation of two independent alleles by crossing the parental mouse line to either a germline expressed FLP recombinase or a germline expressed Cre recombinase mouse. This generated a conditional allele, with the critical exon 1C flanked by loxP sites (Fgf18flox).
(J:279323)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Fgf18 Mutation: |
10 strains or lines available
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Original: |
J:279323 Hagan AS, et al., Generation and validation of novel conditional flox and inducible Cre alleles targeting fibroblast growth factor 18 (Fgf18). Dev Dyn. 2019 Sep;248(9):882-893 |
All: |
3 reference(s) |
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