Sting1tm3.1Camb
Targeted Allele Detail
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Symbol: |
Sting1tm3.1Camb |
Name: |
stimulator of interferon response cGAMP interactor 1; targeted mutation 3.1, John Cambier |
MGI ID: |
MGI:6379578 |
Synonyms: |
STING-R231H |
Gene: |
Sting1 Location: Chr18:35866732-35873607 bp, - strand Genetic Position: Chr18, 19.23 cM, cytoband B3
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Alliance: |
Sting1tm3.1Camb page
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Germline Transmission: |
Earliest citation of germline transmission:
J:331747
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Parent Cell Line: |
JM8A3 (ES Cell)
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Strain of Origin: |
C57BL/6N-Atm1Brd
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Allele Type: |
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Targeted (Humanized sequence) |
Mutation: |
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Nucleotide substitutions
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Mutation details: The targeting vector is designed to insert an FRT-flanked neomycin resistance (neo) cassette downstream of exon 5 of the gene. Exon 6 was modified to harbor mutation (R231H) equivalent to the most common alternative allelic variant of Sting found in humans (R232H). Flp-mediated recombination removed the FRT-flanked neo cassette.
(J:331747)
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Original: |
J:331747 Walker MM, et al., Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H. Front Immunol. 2020;11:238 |
All: |
1 reference(s) |
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