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Sting1tm3.1Camb
Targeted Allele Detail
Summary
Symbol: Sting1tm3.1Camb
Name: stimulator of interferon response cGAMP interactor 1; targeted mutation 3.1, John Cambier
MGI ID: MGI:6379578
Synonyms: STING-R231H
Gene: Sting1  Location: Chr18:35866732-35873607 bp, - strand  Genetic Position: Chr18, 19.23 cM, cytoband B3
Alliance: Sting1tm3.1Camb page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:331747
Parent Cell Line:  JM8A3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutation:    Nucleotide substitutions
 
Mutation detailsThe targeting vector is designed to insert an FRT-flanked neomycin resistance (neo) cassette downstream of exon 5 of the gene. Exon 6 was modified to harbor mutation (R231H) equivalent to the most common alternative allelic variant of Sting found in humans (R232H). Flp-mediated recombination removed the FRT-flanked neo cassette. (J:331747)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sting1 Mutation:  51 strains or lines available
References
Original:  J:331747 Walker MM, et al., Selective Loss of Responsiveness to Exogenous but Not Endogenous Cyclic-Dinucleotides in Mice Expressing STING-R231H. Front Immunol. 2020;11:238
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory