Resttm1.2Bban
Targeted Allele Detail
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Symbol: |
Resttm1.2Bban |
Name: |
RE1-silencing transcription factor; targeted mutation 1.2, Botond Banfi |
MGI ID: |
MGI:6378686 |
Synonyms: |
RestdeltaEx4 |
Gene: |
Rest Location: Chr5:77413338-77434279 bp, + strand Genetic Position: Chr5, 41.61 cM
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Alliance: |
Resttm1.2Bban page
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Germline Transmission: |
Earliest citation of germline transmission:
J:265659
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Modified isoform(s)) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A loxP site and a frt-flanked neomycin resistance gene were inserted upstream of exon 4 and a second loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the selection cassette and cre-mediated recombination deleted exon 4. Deletion of exon 4 prevents the production of the exon4-containing splice form without reducing expression of the form lacking this exon.
(J:265659)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Rest Mutation: |
95 strains or lines available
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Original: |
J:265659 Nakano Y, et al., Defects in the Alternative Splicing-Dependent Regulation of REST Cause Deafness. Cell. 2018 Jul 26;174(3):536-548.e21 |
All: |
2 reference(s) |
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