Tnip2^tm1Pcoh
Targeted Allele Detail

Summary

• Symbol: Tnip2^tm1Pcoh
• Name: TNFAIP3 interacting protein 2; targeted mutation 1, Philip Cohen
• MGI ID: MGI:6378552
• Synonyms: Tnip2^{tm1(D310N)Pcoh}
• Gene: Tnip2 Location: Chr5:34653440-34671323 bp, - strand Genetic Position: Chr5, 17.89 cM
• Alliance: Tnip2^tm1Pcoh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:267760
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A loxP site was inserted upstream of exon 4. Exon 5 is replaced with a modified exon 5 coding for the amino acid substitution of asparagine for aspartic acid at position 310 (D310N). An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted downstream of the modified exon 5. (J:267760)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tnip2 Mutation: 21 strains or lines available

References

• Original: J:267760 Nanda SK, et al., ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism. J Immunol. 2018 Dec 1;201(11):3373-3382
• All: 1 reference(s)