Bdnf^tm2.1Kmrt
Targeted Allele Detail

Summary

• Symbol: Bdnf^tm2.1Kmrt
• Name: brain derived neurotrophic factor; targeted mutation 2.1, Keri Martinowich
• MGI ID: MGI:6378535
• Synonyms: Bdnf-e2^-
• Gene: Bdnf Location: Chr2:109505045-109557352 bp, + strand Genetic Position: Chr2, 56.63 cM
• Alliance: Bdnf^tm2.1Kmrt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269842
• Parent Cell Line: v6.4 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector is designed to insert an enhanced green fluorescent protein (EGFP)-STOP cassette, followed by a loxP-flanked neomycin selection cassette (neo) in reverse orientation, upstream of the splice donor site of exon 2.Cre-mediated recombination removed the floxed neo cassette. (J:269842)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bdnf Mutation: 41 strains or lines available

References

• Original: J:269842 Maynard KR, et al., Functional Role of BDNF Production from Unique Promoters in Aggression and Serotonin Signaling. Neuropsychopharmacology. 2016 Jul;41(8):1943-55
• All: 2 reference(s)