Kat8^tm1Ydou
Targeted Allele Detail

Summary

• Symbol: Kat8^tm1Ydou
• Name: K(lysine) acetyltransferase 8; targeted mutation 1, Yali Dou
• MGI ID: MGI:6376219
• Synonyms: Mof^flox
• Gene: Kat8 Location: Chr7:127511689-127525010 bp, + strand Genetic Position: Chr7, 69.83 cM
• Alliance: Kat8^tm1Ydou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:273170
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The targeting vector was constructed to have a loxP site inserted between exons 3 and 4 and a neomycin gene selection cassette flanked by two loxP sites introduced between exons 6 and 7. The exons 4 to 6 will be deleted upon the expression of Cre recombinase. (J:273170)

Expression

In Mice Carrying this Mutation:

2 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kat8 Mutation: 36 strains or lines available

References

• Original: J:273170 Li X, et al., MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1. Mol Cell Biol. 2010 Nov;30(22):5335-47
• All: 9 reference(s)