Cx3cr1^{tm1.1(CX3CR1)Aeca}
Targeted Allele Detail

Summary

• Symbol: Cx3cr1^{tm1.1(CX3CR1)Aeca}
• Name: C-X3-C motif chemokine receptor 1; targeted mutation 1.1, Astrid E Cardona
• MGI ID: MGI:6376130
• Synonyms: hCX3CR1^I249/M280
• Gene: Cx3cr1 Location: Chr9:119877749-119897362 bp, - strand Genetic Position: Chr9, 71.37 cM
• Alliance: Cx3cr1^{tm1.1(CX3CR1)Aeca} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276012
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6 and 129

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Cx3cr1^{tm1.1(CX3CR1)Aeca} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CX3CR1 (1524)

  Cx3cr1

  (MGI:1333815)

  I249/M280 variant

• Mutation details: The coding sequence was replaced with a splice acceptor and human cDNA with the I249/M280 variant flanked by the mouse 5' and 3' untranslated regions. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downsteam of the human sequence. (J:276012)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cx3cr1 Mutation: 49 strains or lines available

References

• Original: J:276012 Cardona SM, et al., Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1(I249/M280) Variant. Front Cell Neurosci. 2018;12:365
• All: 4 reference(s)