Ngf^tm1Nju
Targeted Allele Detail

Summary

• Symbol: Ngf^tm1Nju
• Name: nerve growth factor; targeted mutation 1, Model Animal Research Center of Nanjing University
• MGI ID: MGI:6376129
• Synonyms: Ngf^fln, NGF^R100W
• Gene: Ngf Location: Chr3:102377235-102428329 bp, + strand Genetic Position: Chr3, 45.25 cM
• Alliance: Ngf^tm1Nju page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276062
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Single point mutation
• Mutation details: Exon 3 contains a point mutation A to T that results in the amino acid substitution of tryptophan for arginine at position 100 (R100W). A floxed neomycin resistance cassette was inserted upstream of the modified exon 3. (J:276062)

Expression

In Mice Carrying this Mutation:

22 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ngf Mutation: 12 strains or lines available

References

• Original: J:276062 Yang W, et al., Targeted Mutation (R100W) of the Gene Encoding NGF Leads to Deficits in the Peripheral Sensory Nervous System. Front Aging Neurosci. 2018;10:373
• All: 1 reference(s)