Abl2^tm2.1Ajk
Targeted Allele Detail

Summary

• Symbol: Abl2^tm2.1Ajk
• Name: ABL proto-oncogene 2, non-receptor tyrosine kinase; targeted mutation 2.1, Anthony J Koleske
• MGI ID: MGI:6369395
• Synonyms: abl2^flox
• Gene: Abl2 Location: Chr1:156386356-156477138 bp, + strand Genetic Position: Chr1, 67.71 cM
• Alliance: Abl2^tm2.1Ajk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:280257
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exon 5. An adjacent loxP-flanked neomyvin selection cassette was removed via Cre-mediated recombination in ES cells prior to the production of chimeric mice. (J:280257)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abl2 Mutation: 81 strains or lines available

References

• Original: J:280257 Kim SY, et al., Transient inhibition of p53 homologs protects ovarian function from two distinct apoptotic pathways triggered by anticancer therapies. Cell Death Differ. 2019 Mar;26(3):502-515
• All: 1 reference(s)