Bag3^tm2.1Chen
Targeted Allele Detail

Summary

• Symbol: Bag3^tm2.1Chen
• Name: BCL2-associated athanogene 3; targeted mutation 2.1, Ju Chen
• MGI ID: MGI:6369096
• Synonyms: Bag3 P209L KI
• Gene: Bag3 Location: Chr7:128125340-128148705 bp, + strand Genetic Position: Chr7, 70.26 cM
• Alliance: Bag3^tm2.1Chen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:272259
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (No functional change)
• Mutation: Single point mutation
• Mutation details: A C to T mutation (c.644C>T) was engineered in exon 3 to change proline codon 215 to a leucine codon (p.P215L). This mutation mimics the p.P209L mutation associated with severe childhood cardiomyopathy in humans. An FRT site flanked neomycin resistance gene cassette that was inserted into intron 2, was removed through subsequent flp-mediated recombination. (J:272259)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bag3 Mutation: 29 strains or lines available

References

• Original: J:272259 Fang X, et al., P209L mutation in Bag3 does not cause cardiomyopathy in mice. Am J Physiol Heart Circ Physiol. 2019 Feb 1;316(2):H392-H399
• All: 1 reference(s)