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Galnt2tm1.2Mrl
Targeted Allele Detail
Nomenclature
Symbol: Galnt2tm1.2Mrl
Name: polypeptide N-acetylgalactosaminyltransferase 2; targeted mutation 1.2, Merck Research Laboratory
MGI ID: MGI:6368825
Gene: Galnt2  Location: Chr8:124231394-124345722 bp, + strand  Genetic Position: Chr8, 72.52 cM, cytoband E2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:251899
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4 to 6 were floxed. Flp-mediated recombination removed the selection cassette. A constitutive KO allele has been generated after Cre-mediated recombination by crossing chimeras to a Cre-Deleter. See https://www.taconic.com/mouse-model/galnt2-ko-9639 for more information. (J:251899)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Galnt2 Mutation:  10 strains or lines available
References
Original:  J:251899 Khetarpal SA, et al., Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents. Cell Metab. 2016 Aug 9;24(2):234-45
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory