Nfib^tm2.1Rmg
Targeted Allele Detail

Summary

• Symbol: Nfib^tm2.1Rmg
• Name: nuclear factor I/B; targeted mutation 2.1, Richard M Gronostajski
• MGI ID: MGI:6368821
• Gene: Nfib Location: Chr4:82208410-82424988 bp, - strand Genetic Position: Chr4, 38.4 cM, cytoband C4-C6
• Alliance: Nfib^tm2.1Rmg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269219
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. The FRT-flanked neo cassette was removed via Flp-mediated recombination in the germline. (J:269219)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfib Mutation: 93 strains or lines available

References

• Original: J:269219 Schanze I, et al., NFIB Haploinsufficiency Is Associated with Intellectual Disability and Macrocephaly. Am J Hum Genet. 2018 Nov 1;103(5):752-768
• All: 2 reference(s)