Cbln1^tm2.1Jim
Targeted Allele Detail

Summary

• Symbol: Cbln1^tm2.1Jim
• Name: cerebellin 1 precursor protein; targeted mutation 2.1, James I Morgan
• MGI ID: MGI:6368818
• Gene: Cbln1 Location: Chr8:88195481-88199220 bp, - strand Genetic Position: Chr8, 42.16 cM
• Alliance: Cbln1^tm2.1Jim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260025
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 2.76-kb DNA region containing exon 3 that encodes the C1q motif was flanked by loxP sites. In addition, a neomycin selection cassette was inserted at the 5' end of the second loxP site. Cre-mediated recombination deleted exon 3 and the neomycin gene. (J:260025)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cbln1 Mutation: 15 strains or lines available

References

• Original: J:260025 Zhang B, et al., Developmental plasticity shapes synaptic phenotypes of autism-associated neuroligin-3 mutations in the calyx of Held. Mol Psychiatry. 2017 Oct;22(10):1483-1491
• All: 1 reference(s)