Ren1^tm2.2Sig
Targeted Allele Detail

Summary

• Symbol: Ren1^tm2.2Sig
• Name: renin 1 structural; targeted mutation 2.2, Curt Sigmund
• MGI ID: MGI:6368628
• Synonyms: renin-b^null
• Gene: Ren1 Location: Chr1:133278412-133288058 bp, + strand Genetic Position: Chr1, 57.91 cM
• Alliance: Ren1^tm2.2Sig page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278974
• Parent Cell Line: iTL IC1 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 1b. An additional loxP site was inserted downstream of exon 1b. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exon 1b. Mice fail to express the brain isoform (renin-b), but express the kideny isoform (renin-a). (J:278974)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ren1 Mutation: 34 strains or lines available

References

• Original: J:278974 Shinohara K, et al., Selective Deletion of the Brain-Specific Isoform of Renin Causes Neurogenic Hypertension. Hypertension. 2016 Dec;68(6):1385-1392
• All: 4 reference(s)