Top6bl^em1Bdm
Endonuclease-mediated Allele Detail

Summary

• Symbol: Top6bl^em1Bdm
• Name: TOP6B like initiator of meiotic double strand breaks; endonuclease-mediated mutation 1, Bernard de Massy
• MGI ID: MGI:6367799
• Synonyms: Top6bl^{em1(W562A)BdM}
• Gene: Top6bl Location: Chr19:4675762-4748696 bp, - strand Genetic Position: Chr19, 4.08 cM
• Alliance: Top6bl^em1Bdm page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Using the CRISPRCas9 technology, donor oligos were designed to change the W562 codon TGG (W) to GCG (A) in the mouse Gm960 gene, and to introduce a silentmutation (A to G) to generate a PstI restriction site. (J:331787)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Top6bl Mutation: 22 strains or lines available

References

• Original: J:331787 Nore A, et al., TOPOVIBL-REC114 interaction regulates meiotic DNA double-strand breaks. Nat Commun. 2022 Nov 17;13(1):7048
• All: 1 reference(s)