Prph2^tm3.1Itl
Targeted Allele Detail

Summary

• Symbol: Prph2^tm3.1Itl
• Name: peripherin 2; targeted mutation 3.1, inGenious Targeting Laboratory
• MGI ID: MGI:6367798
• Synonyms: C150S-Prph2, Prph2^C
• Gene: Prph2 Location: Chr17:47221404-47235859 bp, + strand Genetic Position: Chr17, 22.91 cM
• Alliance: Prph2^tm3.1Itl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266419
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A T to A point mutation was introduced into exon 1 to create a p.C150S substitution in the encoded protein. An FRT and loxP site flanked neomycin selection cassette that was inserted into intron 1, was removed via flp-mediated recombination. (J:266419)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prph2 Mutation: 26 strains or lines available

References

• Original: J:279806 Zulliger R, et al., SNAREs Interact with Retinal Degeneration Slow and Rod Outer Segment Membrane Protein-1 during Conventional and Unconventional Outer Segment Targeting. PLoS One. 2015;10(9):e0138508
• All: 4 reference(s)