Tm7sf2^Sum9-Jus
Chemically induced Allele Detail

Summary

• Symbol: Tm7sf2^Sum9-Jus
• Name: transmembrane 7 superfamily member 2; suppressor of methyl CpG binding protein 2-9, 1 Monica J Justice
• MGI ID: MGI:6367721
• Synonyms: Line 4654
• Gene: Tm7sf2 Location: Chr19:6112851-6117880 bp, - strand Genetic Position: Chr19, 4.34 cM, cytoband A
• Alliance: Tm7sf2^Sum9-Jus page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details:

  This allele was discovered in a screen for attenuation of the Mecp2^tm1.1Bird/Y phenotype among male G1 offspring from crosses of 129S-Mecp2^tm1.1Bird/+ female mice by ENU-treated C57BL/6J males (G0). The mutation has been identified as a T to C point mutation resulting in the amino acid substitution of histidine for tyrosine at position 233 (exon6:c.697T>C:p.Y233H). (J:323637)

• Inheritance: Other (see notes)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tm7sf2 Mutation: 30 strains or lines available

Notes

Dominant modifier

References

• Original: J:323637 Enikanolaiye A, et al., Suppressor mutations in Mecp2-null mice implicate the DNA damage response in Rett syndrome pathology. Genome Res. 2020 Apr;30(4):540-552
• All: 1 reference(s)