Kdm4a^Sum8-Jus
Chemically induced Allele Detail

Summary

• Symbol: Kdm4a^Sum8-Jus
• Name: lysine (K)-specific demethylase 4A; suppressor of methyl CpG binding protein 2-8, 1 Monica J Justice
• MGI ID: MGI:6367720
• Synonyms: Line 520
• Gene: Kdm4a Location: Chr4:117994154-118037216 bp, - strand Genetic Position: Chr4, 54.31 cM
• Alliance: Kdm4a^Sum8-Jus page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU) (Not Specified)
• Mutation: Single point mutation
• Mutation details:

  This allele was discovered in a screen for attenuation of the Mecp2^tm1.1Bird/Y phenotype among male G1 offspring from crosses of 129S-Mecp2^tm1.1Bird/+ female mice by ENU-treated C57BL/6J males (G0). The mutation has been identified as a T to A point mutation in exon 4 that results in the amino acid substitution of a stop codon for tyrosine at position 132 (exon4:c.396T>A:p.Y132X). (J:323637)

• Inheritance: Other (see notes)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kdm4a Mutation: 45 strains or lines available

Notes

Dominant modifier

References

• Original: J:323637 Enikanolaiye A, et al., Suppressor mutations in Mecp2-null mice implicate the DNA damage response in Rett syndrome pathology. Genome Res. 2020 Apr;30(4):540-552
• All: 1 reference(s)