Tg(Myh6-PRKAG2*)H530RBlsg
Transgene Detail

Summary

• Symbol: Tg(Myh6-PRKAG2*)H530RBlsg
• Name: transgene insertion H530R, Bao-Liang Song
• MGI ID: MGI:6367665
• Synonyms: Tg-H530R
• Transgene: Tg(Myh6-PRKAG2*)H530RBlsg Location: unknown
• Alliance: Tg(Myh6-PRKAG2*)H530RBlsg page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-PRKAG2*)H530RBlsg expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PRKAG2 (51422)

  Prkag2

  (MGI:1336153)

  Contains human cDNA with p.His530Arg mutation

• Mutation details: The transgene contains the following elements: mouse Myh6 promoter, human PRKAG2 cDNA with a generated c.1589A>G point mutation, and human GH gene 3' UTR (including poly(A) signal). This mutation, which changes histidine codon 530 to an arginine codon (p.His530Arg), is found in some human familial Wolff-Parkinson-White (WPW) syndrome patients. (J:278059)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:278059 Xie C, et al., Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome. Cell Res. 2016 Oct;26(10):1099-1111
• All: 1 reference(s)