Prkaa1^tm2.1Mfor
Targeted Allele Detail

Summary

• Symbol: Prkaa1^tm2.1Mfor
• Name: protein kinase, AMP-activated, alpha 1 catalytic subunit; targeted mutation 1.1 Marc Foretz
• MGI ID: MGI:6364887
• Synonyms: AMPKalpha1^lox
• Gene: Prkaa1 Location: Chr15:5173343-5211380 bp, + strand Genetic Position: Chr15, 1.99 cM
• Alliance: Prkaa1^tm2.1Mfor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278155
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 5' to exon 4 and an frt-flanked hygromycin selection cassette followed by a second loxP site was inserted 3' to exon 5. The neomycin selection cassette was removed by Flp-mediated recombination in the germline. (J:278155)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkaa1 Mutation: 46 strains or lines available

References

• Original: J:278155 Boudaba N, et al., AMPK Re-Activation Suppresses Hepatic Steatosis but its Downregulation Does Not Promote Fatty Liver Development. EBioMedicine. 2018 Feb;28:194-209
• All: 10 reference(s)