Eif4ebp2^tm1.1Nso
Targeted Allele Detail

Summary

• Symbol: Eif4ebp2^tm1.1Nso
• Name: eukaryotic translation initiation factor 4E binding protein 2; targeted mutation 1.1, Nahum Sonenberg
• MGI ID: MGI:6364845
• Synonyms: Eif4ebp2^flx
• Gene: Eif4ebp2 Location: Chr10:61268276-61288448 bp, - strand Genetic Position: Chr10, 32.21 cM, cytoband B4-B5
• Alliance: Eif4ebp2^tm1.1Nso page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278826
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites and an frt-flanked neomycin selection cassette. The neomycin selection cassette was removed via Flp-mediated recombination in the germline. (J:278826)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eif4ebp2 Mutation: 25 strains or lines available

References

• Original: J:278826 Wiebe S, et al., Inhibitory interneurons mediate autism-associated behaviors via 4E-BP2. Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):18060-18067
• All: 4 reference(s)