Dicer1^em1Glo
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dicer1^em1Glo
• Name: dicer 1, ribonuclease type III; endonuclease-mediated mutation 1, Guillermina Lozano
• MGI ID: MGI:6364599
• Synonyms: Dicer^S1712D
• Gene: Dicer1 Location: Chr12:104654001-104718211 bp, - strand Genetic Position: Chr12, 54.83 cM, cytoband E-F1
• Alliance: Dicer1^em1Glo page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Constitutively active)
• Mutation: Nucleotide substitutions
• Mutation details: This allele was generated using CRISPR/Cas9 technology with an sgRNA and a template oligonucleotide. Serine codon 1712 (TCT) was replaced with a aspartic acid codon (GAC), which creates a phosphomimetic p.S1712D mutation that leads to a constitutively active enzyme. (J:278360)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dicer1 Mutation: 96 strains or lines available

References

• Original: J:278360 Aryal NK, et al., Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo. Proc Natl Acad Sci U S A. 2019 Jan 15;116(3):960-969
• All: 1 reference(s)