Mapk10^tm2.1Flv
Targeted Allele Detail

Summary

• Symbol: Mapk10^tm2.1Flv
• Name: mitogen-activated protein kinase 10; targeted mutation 2.1, Richard A Flavell
• MGI ID: MGI:6364581
• Synonyms: Mapk10^LoxP
• Gene: Mapk10 Location: Chr5:103056413-103359200 bp, - strand Genetic Position: Chr5, 49.61 cM, cytoband E4
• Alliance: Mapk10^tm2.1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:231078
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and an frt-flanked neomycin selection cassette were inserted upstream of exon 7 and a single loxP site was inserted downstream of exon 8. The neomycin selection cassette was removed via Flp-mediated recombination. (J:231078)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk10 Mutation: 35 strains or lines available

References

• Original: J:231078 Vernia S, et al., Excitatory transmission onto AgRP neurons is regulated by cJun NH2-terminal kinase 3 in response to metabolic stress. Elife. 2016;5:e10031
• All: 2 reference(s)