Gria3^tm1Ksak
Targeted Allele Detail

Summary

• Symbol: Gria3^tm1Ksak
• Name: glutamate receptor, ionotropic, AMPA3 (alpha 3); targeted mutation 1, Kenji Sakimura
• MGI ID: MGI:6363975
• Synonyms: Gria3^flox
• Gene: Gria3 Location: ChrX:40489731-40767478 bp, + strand Genetic Position: ChrX, 23.19 cM
• Alliance: Gria3^tm1Ksak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:279639
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A DNA fragment that contained a loxP sequence and pgk-1 promoter-driven neomycin phosphotransferase gene (Neo cassette) flanked by two Flp recognition target (frt) sites was inserted into a site 107 bp upstream of exon 11. The pgk-1 polyadenylation (poly-A) signal sequence was inserted downstream of the Neo cassette. The other loxP site was introduced into a site 113 bp downstream of exon 11 to eliminate the putative transmembrane domain after Cre-mediated recombination. (J:279639)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gria3 Mutation: 10 strains or lines available

References

• Original: J:279639 Rubio ME, et al., The number and distribution of AMPA receptor channels containing fast kinetic GluA3 and GluA4 subunits at auditory nerve synapses depend on the target cells. Brain Struct Funct. 2017 Nov;222(8):3375-3393
• All: 1 reference(s)