Grin2a^tm1Ksak
Targeted Allele Detail

Summary

• Symbol: Grin2a^tm1Ksak
• Name: glutamate receptor, ionotropic, NMDA2A (epsilon 1); targeted mutation 1, Kenji Sakimura
• MGI ID: MGI:6363636
• Synonyms: GluN2A^flox
• Gene: Grin2a Location: Chr16:9385762-9813424 bp, - strand Genetic Position: Chr16, 5.28 cM
• Alliance: Grin2a^tm1Ksak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178548
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An frt-flanked pgk-neomycin selection cassette and a loxP site were inserted 216 bp upstream of exon 10. A second loxP site was inserted 260 bp downstream of exon 10. (J:178548)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grin2a Mutation: 67 strains or lines available

References

• Original: J:178548 Gray JA, et al., Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo. Neuron. 2011 Sep 22;71(6):1085-101
• All: 6 reference(s)