Myo3a^em1Jgao
Endonuclease-mediated Allele Detail

Summary

• Symbol: Myo3a^em1Jgao
• Name: myosin IIIA; endonuclease-mediated mutation 1, Jiangang Gao
• MGI ID: MGI:6363571
• Synonyms: Myo3a Y137C
• Gene: Myo3a Location: Chr2:22232316-22508264 bp, + strand Genetic Position: Chr2, 15.15 cM, cytoband A3
• Alliance: Myo3a^em1Jgao page

Mutation origin

• Strain of Origin: CBA/CaJ

Mutation description

• Allele Type: Endonuclease-mediated (Hypomorph)
• Mutation: Single point mutation
• Mutation details: Using CRISPR/Cas9 technology and an sgRNA and a donor oligonucleotide, an A>G (c.410A>G) mutation was introduced that changes tyrosine codon 137 into a cysteine codon (p.Y137C). This mutation mimics the human Y129C mutation associated with age-related hearing loss (ARHL). (J:278835)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myo3a Mutation: 109 strains or lines available

References

• Original: J:278835 Li P, et al., Knock-In Mice with Myo3a Y137C Mutation Displayed Progressive Hearing Loss and Hair Cell Degeneration in the Inner Ear. Neural Plast. 2018;2018:4372913
• All: 1 reference(s)