Trim58tm2313.2Arte
Targeted Allele Detail
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Symbol: |
Trim58tm2313.2Arte |
Name: |
tripartite motif-containing 58; targeted mutation 2313.2, TaconicArtemis |
MGI ID: |
MGI:6362942 |
Gene: |
Trim58 Location: Chr11:58531291-58543230 bp, + strand Genetic Position: Chr11, 36.23 cM
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Alliance: |
Trim58tm2313.2Arte page
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Germline Transmission: |
Earliest citation of germline transmission:
J:279270
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
C57BL/6N
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 3-5 were flanked by loxP sites and a FRT-flanked neomycin resistance gene and F3-flanked puromycin resistance gene were inserted into intron 2 and intron 5, respectively. Flp-mediated recombination removed the selection makers and cre-mediated recombination removed exons 3-5, generating a frameshift from exons 2 to 6 and a premature stop codon in exon 6.
(J:279270)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Trim58 Mutation: |
24 strains or lines available
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Original: |
J:279270 Eyking A, et al., TRIM58 Restrains Intestinal Mucosal Inflammation by Negatively Regulating TLR2 in Myeloid Cells. J Immunol. 2019 Sep 15;203(6):1636-1649 |
All: |
1 reference(s) |
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