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Targeted Allele Detail
Symbol: Trim58tm2313.2Arte
Name: tripartite motif-containing 58; targeted mutation 2313.2, TaconicArtemis
MGI ID: MGI:6362942
Gene: Trim58  Location: Chr11:58640465-58652404 bp, + strand  Genetic Position: Chr11, 36.23 cM
Germline Transmission:  Earliest citation of germline transmission: J:279270
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6N
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 3-5 were flanked by loxP sites and a FRT-flanked neomycin resistance gene and F3-flanked puromycin resistance gene were inserted into intron 2 and intron 5, respectively. Flp-mediated recombination removed the selection makers and cre-mediated recombination removed exons 3-5, generating a frameshift from exons 2 to 6 and a premature stop codon in exon 6. (J:279270)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trim58 Mutation:  0 strains or lines available
Original:  J:279270 Eyking A, et al., TRIM58 Restrains Intestinal Mucosal Inflammation by Negatively Regulating TLR2 in Myeloid Cells. J Immunol. 2019 Sep 15;203(6):1636-1649
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory