Cdkn1a^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Cdkn1a^em1Smoc
• Name: cyclin dependent kinase inhibitor 1A; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6361245
• Synonyms: Cdkn1a^{em1(2A-tdTomato)Smoc}, P21-tdTomato
• Gene: Cdkn1a Location: Chr17:29309953-29319696 bp, + strand Genetic Position: Chr17, 15.12 cM
• Alliance: Cdkn1a^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Reporter)
• Mutation: Insertion
• Mutation details: A tdTomato cDNA was inserted into the stop codon of the gene. A linker encoding a 2A self-cleaving peptide sequence was inserted upstream of the reporter construct to allow simultaneous expression of tdTomato and Cdkn1a. (J:278880)

Expression

In Mice Carrying this Mutation:

4 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkn1a Mutation: 60 strains or lines available

References

• Original: J:278880 Li Y, et al., Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth. Cell Res. 2018 Jul;28(7):775-778
• All: 1 reference(s)