Sfpq^tm1.2Takea
Targeted Allele Detail

Summary

• Symbol: Sfpq^tm1.2Takea
• Name: splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated); targeted mutation 1.2, Akihide Takeuchi
• MGI ID: MGI:6360737
• Gene: Sfpq Location: Chr4:126915117-126930806 bp, + strand Genetic Position: Chr4, 61.2 cM
• Alliance: Sfpq^tm1.2Takea page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:271630
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and FRT flanked neo cassette were inserted in intron 1 and a loxP site was inserted in intron 4 via homologous recombination. Recombinase mediated recombination removed the neo cassette and exons 2 - 4. (J:271630)

Expression

In Mice Carrying this Mutation:

3 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sfpq Mutation: 28 strains or lines available

References

• Original: J:271630 Takeuchi A, et al., Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain. Cell Rep. 2018 May 1;23(5):1326-1341
• All: 1 reference(s)