Nsmf^tm1.1Mrkr
Targeted Allele Detail

Summary

• Symbol: Nsmf^tm1.1Mrkr
• Name: NMDA receptor synaptonuclear signaling and neuronal migration factor; targeted mutation 1.1, Michael R Kreutz
• MGI ID: MGI:6358415
• Synonyms: Jac-loxPdeltaneo
• Gene: Nsmf Location: Chr2:24944370-24952893 bp, + strand Genetic Position: Chr2, 16.94 cM, cytoband A3
• Alliance: Nsmf^tm1.1Mrkr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232404
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into the 5UTR of exon 1, an FRT-flanked PGK-neomycin selection cassette was inserted after exon 2, followed by a loxP site and a third loxP site downstream of exon 3. Flp-mediated recombination removed the selection cassette leaving exons 1-3 floxed. (J:232404)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nsmf Mutation: 18 strains or lines available

References

• Original: J:232404 Spilker C, et al., A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis. PLoS Genet. 2016 Mar;12(3):e1005907
• All: 1 reference(s)