Bcl10^tm1.1Jrld
Targeted Allele Detail

Summary

• Symbol: Bcl10^tm1.1Jrld
• Name: B cell leukemia/lymphoma 10; targeted mutation 1.1, Jurgen Ruland
• MGI ID: MGI:6358379
• Synonyms: Bcl10^fl
• Gene: Bcl10 Location: Chr3:145630017-145640121 bp, + strand Genetic Position: Chr3, 71.03 cM, cytoband H3
• Alliance: Bcl10^tm1.1Jrld page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278509
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The allele flanking exon 2 of Bcl10 with loxP sites was generated with the targeting construct containing a 0.7 kb short arm (SA) of Bcl10 intron 1, a frt-flanked neomycin resistance cassette followed by a 1.3 kb loxP flanked conditional arm comprising exon 2 and a 5 kb long arm, including exon 3 of the Bcl10 locus. Chimeric mice were mated for germline transmission of the targeted Bcl10 allele and crossed with ACT-FLPe mice to delete the neomycin resistance cassette. (J:278509)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl10 Mutation: 18 strains or lines available

References

• Original: J:278509 Rosenbaum M, et al., Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells. Nat Commun. 2019 May 28;10(1):2352
• All: 2 reference(s)