Slc12a4^tm1.1Cahb
Targeted Allele Detail

Summary

• Symbol: Slc12a4^tm1.1Cahb
• Name: solute carrier family 12, member 4; targeted mutation 1.1, Christian Hubner
• MGI ID: MGI:6358351
• Synonyms: Kcc1^-
• Gene: Slc12a4 Location: Chr8:106670222-106692729 bp, - strand Genetic Position: Chr8, 53.06 cM
• Alliance: Slc12a4^tm1.1Cahb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:122087
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The region encompassing exons 4 and 5 was flanked by loxP sites. A loxP site was inserted into the intron between exons 5 and 6 by PCR mutagenesis and a floxed neomycin resistance (neo) cassette was inserted between exons 3 and 4. (J:122087)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc12a4 Mutation: 53 strains or lines available

References

• Original: J:122087 Rust MB, et al., Disruption of erythroid K-Cl cotransporters alters erythrocyte volume and partially rescues erythrocyte dehydration in SAD mice. J Clin Invest. 2007 Jun;117(6):1708-17
• All: 4 reference(s)