Slc25a46^em1Rstot
Endonuclease-mediated Allele Detail

Summary

• Symbol: Slc25a46^em1Rstot
• Name: solute carrier family 25, member 46; endonuclease-mediated mutation 1, Rolf Stottmann
• MGI ID: MGI:6358090
• Gene: Slc25a46 Location: Chr18:31713217-31743585 bp, - strand Genetic Position: Chr18, 17.79 cM
• Alliance: Slc25a46^em1Rstot page

Mutation origin

• Strain of Origin: B6D2F2

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to induce a 46-bp deletion in exon 8. The deletion causes a frameshift and a subsequent stop codon 15 amino acids downstream of the deleted sequences in the encoded protein. (J:251671)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc25a46 Mutation: 24 strains or lines available

References

• Original: J:251671 Li Z, et al., Loss of SLC25A46 causes neurodegeneration by affecting mitochondrial dynamics and energy production in mice. Hum Mol Genet. 2017 Oct 01;26(19):3776-3791
• All: 2 reference(s)