Dnase1l3^tm1.1Twin
Targeted Allele Detail

Summary

• Symbol: Dnase1l3^tm1.1Twin
• Name: deoxyribonuclease 1-like 3; targeted mutation 1.1, Thomas H Winkler
• MGI ID: MGI:6358024
• Synonyms: Dnase1l3^deltaex2
• Gene: Dnase1l3 Location: Chr14:14475014-14504586 bp, + strand Genetic Position: Chr14, 4.67 cM, cytoband A1
• Alliance: Dnase1l3^tm1.1Twin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264769
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was obtained from the KOMP consortium (project CSD48807, clone HTGRS01006_A_B09) and transfected to V6.5 ES cells. An frt-lacZ-loxP-neomycin selection cassette-frt-loxp construnct was inserted into intron 1 and a single loxP site was inserted into intron 2. Cre-mediated recombination in the germline resulted in the deletion of exon 2. (J:264769)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dnase1l3 Mutation: 26 strains or lines available

References

• Original: J:264769 Weisenburger T, et al., Epistatic Interactions Between Mutations of Deoxyribonuclease 1-Like 3 and the Inhibitory Fc Gamma Receptor IIB Result in Very Early and Massive Autoantibodies Against Double-Stranded DNA. Front Immunol. 2018;9:1551
• All: 2 reference(s)