Tnfsf11^em1Caob
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tnfsf11^em1Caob
• Name: tumor necrosis factor (ligand) superfamily, member 11; endonuclease-mediated mutation 1, Charles O'Brien
• MGI ID: MGI:6358014
• Synonyms: sRANKL
• Gene: Tnfsf11 Location: Chr14:78514886-78545483 bp, - strand Genetic Position: Chr14, 41.26 cM
• Alliance: Tnfsf11^em1Caob page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Not Applicable)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to create a deletion of sequences encoding the stalk domain, which contains all known proteolytic cleavage sites. The protein encoded by the modified allele lacks amino acids Ile133 to Ser149 and contains Arg at the former Trp150 position. (J:266262)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfsf11 Mutation: 30 strains or lines available

References

• Original: J:266262 Xiong J, et al., Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss. Nat Commun. 2018 Jul 25;9(1):2909
• All: 2 reference(s)