Cxcl10^tm1.1Dple
Targeted Allele Detail

Summary

• Symbol: Cxcl10^tm1.1Dple
• Name: C-X-C motif chemokine ligand 10; targeted mutation 1, David Pleasure
• MGI ID: MGI:6357982
• Synonyms: CXCL10^fl
• Gene: Cxcl10 Location: Chr5:92494497-92496748 bp, - strand Genetic Position: Chr5, 46.57 cM
• Alliance: Cxcl10^tm1.1Dple page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:278189
• Parent Cell Line: JM8.F6 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exons 2 and 3. An frt-flanked neomycin selection cassette was removed via FLP-mediated recombination. (J:278189)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cxcl10 Mutation: 21 strains or lines available

References

• Original: J:278189 Mills Ko E, et al., Deletion of astroglial CXCL10 delays clinical onset but does not affect progressive axon loss in a murine autoimmune multiple sclerosis model. J Neuroinflammation. 2014 Jun 12;11:105
• All: 3 reference(s)